The European invasion of the Americas

Desease, no, Genocide (a hilariuosly politicaly loaded term) tends to suggest intent, those Spaniards didn't intent to kill them off with Small Pox anymore than those Indians intended to get Europeans addicted to Tobacco.
As for the Later US involvement, there was an intent to take there land, which at the very least suggests ethnic cleansing, whether there was an explicit intent to kill them all, or merely a cronic indifference to their fate in the thirst for farm land, i don't know. There may not seem a fantastic difference between the to on the ends front, but policitos will argue over inane sematics when it comes to the word genocide, just look at Sudan.

yes but thats barely comparable, 90% of Native Americans died from European diseases on teh whole, a few million palefaces died of syphillis, though it was gruesome.

However I agree it wasnt genocide at all.  The Spanish would have prefered then natives to live for labor purposes, and their death brought about the needing of the slave trade from Africa.  In a similair fashion the US westward expansion was based more on resources and appeasing populace, most creulties were more likely to happen because of settlers and their culture than official government policy.  Nonetheless it still could count as cultural genocide, with the reservations and the forced adoption of farming.

The wrost was the school systems who would beat students who spoke in native toungue or did not convert to christianity.

Originally posted by Tobodai yes but thats barely comparable, 90% of Native Americans died from European diseases on teh whole, a few million palefaces died of syphillis, though it was gruesome.

It's got to be remembered small pox is quite preventable but syphilis is still rampant, it's been killing for 5 hundred years now, that's quite some total. Also it's spread from Europe to Asia and Africa and rampant in places with little medical care. 90,000 people a year die from it in Africa alone. I wondered which really has killed the most.