Yes.
The incas and Aztecs belonged to the two main cultural areas of the Americas, the Peruvian and the Mesoamerican, respectively. For all purposes, those cultural areas were isolated.
Sometimes I wonder what would happened if Peruvians and Mexicans entered in contact before. Writing and wheels for example could have spread to Peru, and Llamas, hunging bridges, seagoing vesels and thousand of other technologies could have reached Mexico. Perhaps that could have started a new age of achievements that could have prompted the Amerindians civilizations to a more advanced level of development.
It didn't happened, and the Europeans came first, bringing with them a civilization that was, in material and technological terms, superior to the Amerindian, and replacing that in a relatively short time. Truncating forever what could have been some of the most original civilizations in the planet.
When I see the archaelogical remains of those great ancient people I feel pain about that. It is imposible to forget them living in theirs ancient lands.
Pinguin