Identical MHC Markers in Non-Jewish Iranian and Ashkenazi Jewish
Patients with Pemphigus Vulgaris: Possible Common Central Asian
Ancestral Origin
Narciss MobiniA, Edmond J. YunisB, C, D, E, *, Chester A. AlperB, F, *, Juan J. YunisB, C, Julio C. DelgadoC, E, David E. YunisB, AliReza FiroozA, Yahya DowlatiG, Kamal BaharH, Peter K. GregersenI and A. Razzzaque AhmedA, B
ABSTRACT: Previous studies showed that almost all Ashkenazi Jewish
patients with pemphigus vulgaris carried the extended haplotype [HLA-B38, SC21, DRB1*0402, DQB1*0302] or [HLA-B35, SC31, DRB1*0402, DQB1*0302] or class II fragments of them. Non-Jewish patients carried [HLA-B55, SB45, DRB1*1401, DQB1*0503] or its class II fragments. In the present study of 20 Iranian patients with pemphigus vulgaris, 17 were found to carry DRB1*0402, DQB1*0302
haplotypes, also found among normal Iranian haplotypes and the same as
that of the Jews. These findings suggest that the pemphigus MHC
susceptibility gene among Iranians derived from the same ancestor as
that in the Ashkenazim. The ancient Jews were under Persian domination
from 500 B.C. until 300 B.C. and in the 8th century A.D., a Tataric
people living in the kingdom of Khazar on the Western shore of the
Caspian Sea and the Northern shore of the Black Sea, near Persia,
converted to Judaism, providing possible opportunities for gene mixing
in two populations that are distinct and separate today.
The lab I work in has rights to "Science Direct" hosted papers, so I'll host the .pdf file soon.
and in the 8th century A.D., a Tataric people living in the kingdom of Khazar on the Western shore of the Caspian Sea and the Northern shore of the Black Sea, near Persia,
They were not Tataric. There is not that kind of therminology. Khazars were Turkic.
It's true that the tartars were likely "turkic" in origin, but they
were far removed from other turkic tribes. Regardless, that is merely a
historical hypothesis they forwarded, the facts they provide speak for
themselves. The study drew upon
random ethnic samples (including Turkic samples), and no sort of
haplotype correlate existed outside of the strong
Ashkenazi-Iranian connection.
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